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Article
Nature Immunology  6, 698 - 706 (2005)
Published online: 5 June 2005; | doi:10.1038/ni1212

CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa

Amale Laouar1, Viraga Haridas1, Dorothy Vargas1, Xia Zhinan2, David Chaplin3, Rene A W van Lier4 & N Manjunath1

1  The CBR Institute for Biomedical Research and Department of Pediatrics, Boston, Massachusetts 02115, USA.

2  Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

3  Department of Microbiology, University of Birmingham, Alabama, 35294 USA.

4  Laboratory for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.

Correspondence should be addressed to N Manjunath swamy@cbr.med.harvard.edu
One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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