Nature Immunology6, 715 - 721 (2005)
Published online: 29 May 2005; | doi:10.1038/ni1211
Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells
Ian M Catlett
& Stephen M Hedrick
The University of California San Diego, La Jolla, California 92093-0377, USA.
Correspondence should be addressed to Stephen M Hedrick shedrick@ucsd.edu
Suppressor of cytokine signaling 1 (Socs1) is critical for the regulation of interferon- responses and T cell homeostasis. Although the presentation of the inflammatory disease of Socs1-deficient mice is complex, we have tested here the hypothesis that it originates from inappropriate T cell development and the appearance of autoreactive T cells. Socs1-deficient T cell receptor−transgenic mice showed severely impaired positive selection and a substantial alteration in CD4-CD8 T cell fate specification. These defects were dependent on interferon-. Moreover, negative selection was also impaired, suggesting that autoimmunity contributes to the disease observed in Socs1-/- mice. We conclude that the constitutive expression of Socs1 in the thymus protects the process of thymic development and selection from the effects of systemic inflammation.
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responses and T cell homeostasis. Although the presentation of the inflammatory disease of Socs1-deficient mice is complex, we have tested here the hypothesis that it originates from inappropriate T cell development and the appearance of autoreactive T cells. Socs1-deficient T cell receptor−transgenic mice showed severely impaired positive selection and a substantial alteration in CD4-CD8 T cell fate specification. These defects were dependent on interferon-
