Cecilia Johansson and Brian L. Kelsall are in the Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. cjohansson@niaid.nih.gov or bkelsall@niaid.nih.gov
After leaving lymphoid tissues, do T cells receive additional signals for survival and differentiation at effector sites? A unique cell population in the intestinal lamina propria may provide such a signal via the costimulatory molecule CD70.
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