Nature Immunology
6, 587 - 592 (2005)
Published online: 1 May 2005; | doi:10.1038/ni1200
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunityAtsushi Matsuzawa, Kaoru Saegusa, Takuya Noguchi, Chiharu Sadamitsu, Hideki Nishitoh, Shigenori Nagai, Shigeo Koyasu, Kunihiro Matsumoto, Kohsuke Takeda
& Hidenori IchijoSupplementary Fig. 1 (pdf 72K)
LPS-induced expression of inducible NO synthase (iNOS) is reduced in ASK1-deficient DCs. Supplementary Fig. 2 (pdf 112K)
Normal expression of TLR4−MD-2 in ASK1-deficient cells and inhibitory effects of p38 inhibitor on LPS-induced cytokine productions. Supplementary Fig. 3 (pdf 316K)
PGN-induced IL-6 production in ASK1-deficient splenocytes and inability of poly(I:C) and CpG on ASK1 activation. Supplementary Fig. 4 (pdf 200K)
ASK1 is not essential for TLR2-dependent pathway. Supplementary Fig. 5 (pdf 200K)
ROS-dependent endogenous interaction between TRAF6 and ASK1 induced by LPS. Supplementary Fig. 6 (pdf 144K)
Specificity of TRAF6 antibody
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