Transcription factors of the NF-B family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-B activation is cytoplasmic and leads to the release of NF-B proteins from IB molecules, specific inhibitors that prevent their nuclear accumulation. However, it is becoming increasingly apparent that in addition to this required activation step, both recruitment of NF-B to target genes and NF-B-induced transcriptional events after recruitment are actively controlled. Regulated recruitment of NF-B to chromatin generates kinetic complexity in NF-B-dependent gene induction and 'wires' NF-B-regulated gene activity to simultaneously activated pathways and transcription factors.
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B with chromatin: the art of being at the right place at the right time
B family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-
