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Article
Nature Immunology  6, 507 - 514 (2005)
Published online: 10 April 2005; | doi:10.1038/ni1192

Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

Monica Rimoldi1, Marcello Chieppa2, 7, Valentina Salucci1, Francesca Avogadri1, Angelica Sonzogni3, Gianluca M Sampietro4, Angelo Nespoli5, Giuseppe Viale3, 6, Paola Allavena2 & Maria Rescigno1

1  Department of Experimental Oncology, European Institute of Oncology, I-20141 Milan, Italy.

2  Department of Immunology, Istituto di Ricerche Farmacologiche 'Mario Negri', 20157 Milan, Italy.

3  Department of Pathology and Laboratory Medicine, European Institute of Oncology, I-20141 Milan, Italy.

4  Division of General Surgery, University of Milan and Luigi Sacco Hospital, Milan 20157, Italy.

5  University of Milano-Bicocca and San Gerardo Hospital, Monza, Milan 20052, Italy.

6  University of Milan School of Medicine, Milan 20141, Italy.

7  Present address: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Correspondence should be addressed to Maria Rescigno maria.rescigno@ifom-ieo-campus.it
The control of damaging inflammation by the mucosal immune system in response to commensal and harmful ingested bacteria is unknown. Here we show epithelial cells conditioned mucosal dendritic cells through the constitutive release of thymic stromal lymphopoietin and other mediators, resulting in the induction of 'noninflammatory' dendritic cells. Epithelial cell−conditioned dendritic cells released interleukins 10 and 6 but not interleukin 12, and they promoted the polarization of T cells toward a 'classical' noninflammatory T helper type 2 response, even after exposure to a T helper type 1−inducing pathogen. This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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