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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Immunology  6, 430 - 432 (2005) doi:10.1038/ni0505-430 HIV pathogenesis: the first cut is the deepest Louis J Picker1 & David I Watkins2 1  Louis J. Picker is with the Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006, USA. 2  David I. Watkins is with the Wisconsin National Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA. watkins@primate.wisc.edu HIV pathogenesis is thought of as a chronic infection involving slow degradation of immunity that ultimately leads to AIDS. This scenario, however, could reflect the decay of an immune system mortally wounded during acute HIV infection. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWS Gut microbes out of control in HIV infection Nature Medicine News and Views (01 Dec 2006) HIV swiftly guts the immune system Nature Medicine News and Views (01 May 2005) See all 3 matches for News And Views RESEARCH Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination Mucosal Immunology Article Response Monitoring α4β7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection Mucosal Immunology Article Response See all 14 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... Optimizing Sub-cellular Localization Tags Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... More Challenges Powered by: nature jobs PhD - Helmholtz International Graduate School for Infection Research Helmholtz-Zentrum fur Infektionsforschung Braunschweig Germany Sr. Scientific Manager / Chief Scientific Manager- Discovery Metabolism and Pharmacokinetics (MAP) Syngene International Bangalore, Karnataka 560099 India More science jobs Post a job for free Figures & Tables Export citation Search buyers guide:   ADVERTISEMENT

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