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Article
Nature Immunology  6, 412 - 418 (2005)
Published online: 20 February 2005; | doi:10.1038/ni1174

Immune activation modulates hematopoiesis through interactions between CD27 and CD70

Martijn A Nolte1, 2, 5, Ramon Arens1, 2, 5, Ronald van Os3, Michiel van Oosterwijk1, 2, Berend Hooibrink4, René A W van Lier2 & Marinus H J van Oers1

1  Department of Hematology, F4-224, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

2  Department of Experimental Immunology, L1-105, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

3  Department of Cell Biology, Division Stem Cell Biology, University of Groningen, 9713 AV, Groningen, The Netherlands.

4  Department of Cell Biology and Histology, L3-362, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.

5  Present addresses: Immunobiology Laboratory, Cancer Research UK, Lincoln's Inn Fields Laboratories, London WC2A 3PX, UK (M.N.) and Division of Immunology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, Netherlands (R.A.).

Correspondence should be addressed to René A W van Lier r.vanlier@amc.uva.nl
The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony−forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27+ progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation.

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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