E. Yvonne Jones is in the Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK. yvonne@strubi.ox.ac.uk
Different peptide antigens induce T cell repertoires of very different diversity. An analysis of the effect on T cell receptor usage of re-engineering peptide features indicates that a lack of prominent side chains presented for recognition limits the T cell repertoire.
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