Switching sides: transcriptional control of CD4 thymocyte lineage commitment
Rose Zamoyska
Rose Zamoyska is with Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 4RD, UK. rzamoys@nimr.mrc.ac.uk
Double-positive thymocytes are selected into the CD4 or CD8 lineage on the basis of their T cell receptor specificity. The transcription factor cKrox has been identified as being both required and sufficient to direct thymocytes undergoing positive selection to the CD4 lineage.
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