T cell receptor CDRs: starring versus supporting roles
David M Kranz
David M. Kranz is in the Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA. d-kranz@uiuc.edu
Specific docking of the three T cell receptor complementary-determining regions (CDRs) onto the peptide-MHC complex is the basis of immune recognition. However, the contribution of each CDR to peptide-MHC binding is not routine.
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