Nature Immunology 6, 1198 - 1205 (2005)
Published online: 17 November 2005; | doi:10.1038/ni1274
Limiting inflammatory responses during activation of innate immunityJiahuai Han1, 2
& Richard J Ulevitch21
The Key Laboratory of The Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China. 2
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.
Correspondence should be addressed to Jiahuai Han jhan@scripps.edu The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well understood that resolution of inflammation is essential for maintaining the balance between health and disease. When the normal regulatory mechanisms are disturbed, the potential for developing chronic inflammatory diseases is increased. Inflammation is a key element in the response of the innate immune system to a variety of challenges, including those provided by bacterial and viral infection as well as by damaged or dying host cells. Here we review elements of innate immunity that lead to inflammation and some of the host mechanisms that allow for the resolution of the inflammatory responses.
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