Nature Immunology 6, 1213 - 1214 (2005)
doi:10.1038/ni1205-1213
Microclusters initiate and sustain T cell signalingAlain Trautmann
Alain Trautmann is with Institut National de la Santé et de la Recherche Médicale, U567 Paris; Centre National Recherche Scientifique, UMR 8104 Paris; Université Paris Descartes, UMR-S 8104 Paris; and Institut Cochin, 75014 Paris, France. trautmann@cochin.inserm.fr
The elementary molecular structure responsible for initiating T cell receptor signaling is unknown. Distinct microclusters of a few tens of molecules may accomplish this.
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