Ganes C. Sen and Saumendra N. Sarkar are in the Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. seng@ccf.org
The cellular RNA helicase RIG-I initiates an antiviral response through the activation of several protein kinases. The physical link between RIG-I and these 'downstream' kinases has now been identified.
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