Shannon T. Bailey and Sankar Ghosh are in the Section of Immunobiology and Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06519, USA. sankar.ghosh@yale.edu
Although it often acts as a transcriptional activator, the nuclear hormone receptor PPAR- also 'transrepresses' inflammatory responses mediated by the transcription factor NF-B. New data demonstrate that sumoylation of PPAR- leads to the retention of repressor complexes on promoters of inflammatory genes.
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also 'transrepresses' inflammatory responses mediated by the transcription factor NF-
B. New data demonstrate that sumoylation of PPAR-
