Xiaosheng Wu and Diane F. Jelinek are in the Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. jelinek.diane@mayo.edu
Germinal center formation requires BCL6 to silence specific genes in B cells. New data now show that the repertoire of genes repressed by BCL6 is larger than previously thought, because of its interaction with the DNA-binding protein Miz-1.
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