An important clue: fingerprints point to psoriasin in defense against E. coli
Charles L Bevins
Charles L. Bevins is in the Department of Medical Microbiology and Immunology, School of Medicine, University of California, Tupper Hall Rm 3146, One Sheilds Avenue, Davis, California 95616, USA clbevins@ucdavis.edu
Human skin is surprisingly resistant to colonization by Escherichia coli, a prevalent commensal bacterium of the gut flora. An 11-kDa Zn2+-binding protein, psoriasin, is identified as the principal E. coli−bactericidal factor present at the surface of human skin.
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