John J. O'Shea and Wendy Watford are with the Molecular Immunology and Inflammation Branch of the National Institute of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland 20852, USA. osheajo@mail.nih.gov
Members of the PIAS family can negatively regulate the cytokine-activated Jak-STAT pathway in vitro. One member of this family, PIAS1, is a nonredundant and physiologic regulator of certain STAT1-dependent interferon-induced genes.
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