Environmental conservation: bystander CD4 T cells keep CD8 memories fresh
Sara E Hamilton, Martin Prlic
& Stephen C Jameson
Sara E. Hamilton, Martin Prlic and Stephen C. Jameson are at the Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA. james024@umn.edu.
CD4+ T cells reportedly program CD8+ T cells to develop into suitable memory cells during the primary immune response. However, new data indicate that the maintenance of CD8+ memory T cells requires continuous exposure to bystander CD4+ T cells.
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