Mathias W Hornef1, 2, 5, Katrin Pütsep3, 5, Jenny Karlsson3, Essam Refai4
& Mats Andersson31
Institute of Medical Microbiology and Hygiene, University of Freiburg, D-79104 Freiburg, Germany.
2
Swedish Institute for Infectious Disease Control (SMI), SE-17182 Solna, Sweden.
3
Microbiology and Tumor Biology Center, Karolinska Institute, SE-17177 Stockholm, Sweden.
4
Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-17177 Stockholm, Sweden.
5
These authors contributed equally to this work.
Correspondence should be addressed to Mats Andersson mats.andersson@mtc.ki.se
-defensins. CRS peptides caused rapid and potent killing of commensal and pathogenic bacteria. The CRS peptides formed homo- and heterodimers in vivo, thereby expanding the repertoire of antimicrobial peptides and increasing the peptide diversity of Paneth cell secretions. CRS peptides might therefore be important in the maintenance of the microbial homeostasis within the intestinal tract.
