David T. Scadden is at Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Room 5212, Boston, Massachusetts 02129, USA. scadden.david@mgh.harvard.edu
A hierarchy of stem cells has been identified within leukemias, providing a more complex view of how these self-renewing populations parallel the normal stem cell compartment. As the resemblance between normal and malignant stem cells deepens, new opportunities for understanding and treating malignancy emerge.
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