V(D)J recombinational accessibility—heading in the opposite direction?
Cosmas Giallourakis1, Frederick W Alt1
& Craig H Bassing2
1
Cosmas Giallourakis and Frederick W. Alt are at CBR Institute for Biomedical Research and Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. alt@enders.tch.harvard.edu
2
Craig H. Bassing is at CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts 02115, USA.
The assembly of antigen receptor genes in developing lymphocytes through V(D)J recombination is regulated through a mostly undefined but broadly relevant process referred to as 'accessibility'. New findings raise the possibility that wide-ranging, antisense transcription through unrearranged antigen receptor loci could be involved in modulating recombinational accessibility.
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