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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Article Nature Immunology  5, 488 - 494 (2004) Published online: 28 March 2004; | doi:10.1038/ni1060 TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM Carole Couillault1, Nathalie Pujol1, Jérôme Reboul2, Laurence Sabatier3, Jean-François Guichou4, Yuji Kohara5 & Jonathan J Ewbank1 1  Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique/Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France. 2  Institut National de la Santé et de la Recherche Médicale U119, Institut Paoli Calmette, 13009 Marseille, France. 3  Institut de Biologie Moléculaire et Cellulaire, UPR 9022, Centre National de la Recherche Scientifique, 15 rue Descartes, 67084 Strasbourg Cedex, France. 4  Centre de Biochimie Structurale, Centre National de la Recherche Scientifique UMR 5048, Institut National de la Santé et de la Recherche Médicale UMR 554, Université de Montpellier 1, 29, rue de Navacelles, 34090 Montpellier Cedex, France. 5  National Institute of Genetics, Mishima 411, Japan. Correspondence should be addressed to Jonathan J Ewbank ewbank@ciml.univ-mrs.fr.Both plants and animals respond to infection by synthesizing compounds that directly inhibit or kill invading pathogens. We report here the identification of infection-inducible antimicrobial peptides in Caenorhabditis elegans. Expression of two of these peptides, NLP-29 and NLP-31, was differentially regulated by fungal and bacterial infection and was controlled in part by tir-1, which encodes an ortholog of SARM, a Toll−interleukin 1 receptor (TIR) domain protein. Inactivation of tir-1 by RNA interference caused increased susceptibility to infection. We identify protein partners for TIR-1 and show that the small GTPase Rab1 and the f subunit of ATP synthase participate specifically in the control of antimicrobial peptide gene expression. As the activity of tir-1 was independent of the single nematode Toll-like receptor, TIR-1 may represent a component of a previously uncharacterized, but conserved, innate immune signaling pathway. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWS Dissecting worm immunity Nature Immunology News and Views (01 May 2004) DisSARMing Toll-like receptor signaling Nature Immunology News and Views (01 Oct 2006) RESEARCH Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-β signaling pathway in Caenorhabditis elegans epidermis Nature Immunology Article (01 Mar 2009) The human adaptor SARM negatively regulates adaptor protein TRIF?dependent Toll-like receptor signaling Nature Immunology Article (01 Oct 2006) See all 7 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Open Innovation Challenges Optimizing Sub-cellular Localization Tags Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... More Challenges Powered by: nature jobs Head-Preclinical Syngene International Bangalore, Karnataka 560099 India Business Manager Indegene Lifesystems Pvt. Ltd Bengaluru 560 071 India More science jobs Post a job for free Figures & Tables Supplementary info See also: News and Views by Hodgkin Export citation Search buyers guide:   ADVERTISEMENT

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