Gregory M. Barton and Ruslan Medzhitov are in the Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA. gregory.barton@yale.edu or ruslan.medzhitov@yale.edu
Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction by certain TLR family members.
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