Given the right sequence of cues, embryonic stem cells can develop into any cell type found in the body. New work shows how manipulation of supportive stromal cells to provide essential Delta-Notch interactions allows embryonic stem cells to develop into functional T lymphocytes during in vitro culture.
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Rothenberg, E. From totipotency to T in a dish. Nat Immunol 5, 359–360 (2004). https://doi.org/10.1038/ni0404-359
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DOI: https://doi.org/10.1038/ni0404-359
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From stem cell to T cell in vitro
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