New therapeutic key for cystic fibrosis: a role for lipoxins
Daiya Takai, Takahide Nagase
& Takao Shimizu
Daiya Takai and Takahide Nagase are in the Department of Respiratory Medicine and Takao Shimizu is in the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyoku, Tokyo, Japan. tshimizu@m.u-tokyo.ac.jp
One of the hallmarks of cystic fibrosis is the propensity of patients to develop lung infections with Pseudomonas aeruginosa, which eventually compromises lung function. New data suggest loss of CFTR impairs lipoxin production, thus preventing resolution of lung inflammation and creating an environment susceptible to further infection.
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