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News and Views
Nature Immunology  5, 351 - 353 (2004)
doi:10.1038/ni0404-351

Crawling and INTEGRating apical cues

Ronen Alon1 & Francis W Luscinskas2

1  Ronen Alon is in the Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. ronalon@weizmann.ac.il

2  Francis W. Luscinskas is at the Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Leukocytes are arrested on endothelial cells before moving through vessel intercellular junctions. The identification of another beta2 integrin−dependent step may provide insights into the events and signals required for transmigration.

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