Karen W. Makar & Christopher B. Wilson are in the Department of Immunology, Box 357650, University of Washington, Seattle, Washington 98195, USA. cbwilson@u.washington.edu
When acetyl or methyl groups are added to histones, chromatin structure and gene expression are altered. The methyltransferase G9a can target the specific silencing of IFNB gene expression and blocking of V(D)J recombination.
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