CD28-B7 bidirectional signaling: a two-way street to activation
Eric C Logue
& William C Sha
Eric C. Logue and William C. Sha are in the Molecular and Cell Biology Department, University of California, Berkeley, California 94720-3200, USA. bsha@berkeley.edu
Engagement of CD28 by B7 molecules results in the activation of T cells. In addition to this T cell stimulation through CD28, the engagement of B7 on dendritic cells by CD28 can lead to the activation of dendritic cells.
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