Class switching and Myc translocation: how does DNA break?
Paolo Casali
& Hong Zan
Paolo Casali and Hong Zan are at the Center for Immunology, University of California, Irvine, California 92697-4120, USA. pcasali@uci.edu or hzan@uci.edu
Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
