Philip G. Ashton-Rickardt is with the Committees on Immunology and Developmental Biology, Department of Pathology, Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA. pashtonr@midway.uchicago.edu
Many models have been put forth to explain the function of CD4 T cell help in primary and memory CD8 T cell generation. New evidence suggests the licensing model may be the most physiologically relevant.
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