Neal Silverman and Katherine Fitzgerald are in the Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. neal.silverman@umassmed.edu
The innate inflammatory immune response must be finely tuned to avoid excessive damage to the host. One molecule, A20, is intricately involved in dampening inflammatory signals mediated by both tumor necrosis factor and multiple Toll-like receptors.
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