Unmasking connections in transmembrane immune signaling
Jamey D Marth
Jamey D. Marth is with the Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine at the University of California San Diego, La Jolla, California, 92093, USA. jmarth@ucsd.edu
The B cell transmembrane glycoprotein modulates immune signaling. Mice containing specific Cd22 mutations show that the extracellular glycan-binding function is regulatory and indicate unexpected complexity in CD22-ligand interactions.
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