Gérard Eberl1, 5, Shana Marmon1, Mary-Jean Sunshine1, 2, Paul D Rennert3, Yongwon Choi4
& Dan R Littman1, 21
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
2
Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
3
Department of Immunology, Biogen, Cambridge, Massachusetts 02142, USA.
4
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
5
Present address: Aaron Diamond AIDS Research Center, New York, New York 10016, USA.
Correspondence should be addressed to Gérard Eberl geberl@adarc.org or Dan R Littman littman@saturn.med.nyu.edu
t in the generation of fetal lymphoid tissue inducer cells
t is expressed exclusively in and is required for the generation of LTi cells. ROR
1
2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell−mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
