Warner C. Greene is at the Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141, USA. wgreene@gladstone.ucsf.edu
Murr1, a protein linked to copper homeostasis, is shown in a recent Nature paper to inhibit the degradation of IB. This unexpected action of Murr1, which blunts both basal and stimulus-coupled activation of the NF-B transcription factor, is key in making resting CD4 T lymphocytes nonpermissive for HIV infection.
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. This unexpected action of Murr1, which blunts both basal and stimulus-coupled activation of the NF-
