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News and Views
Nature Immunology  5, 12 - 14 (2004)
doi:10.1038/ni0104-12

Lymphoid organogenesis: getting the green light from RORbig gammat

Martin Lipp & Gerd Müller

Martin Lipp and Gerd Müller are in the Department of Molecular Tumor Genetics and Immunogenetics, Max-Delbrueck-Center for Molecular Medicine, MDC, Robert-Roessle-Strasse 10, 13092 Berlin, Germany. mlipp@mdc-berlin.de

Lymphoid tissue inducer (LTi) cells are central to the development of lymphoid organs during embryonic development. Only these cells express the nuclear receptor RORbold gammat, which turns out to be indispensable for LTi cell survival and function.

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