Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
Robert A Seder1
& Rafi Ahmed2
1
Robert A. Seder is at the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3005, USA.
2
Rafi Ahmed is at the Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.
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