Nature Immunology4, 907 - 912 (2003)
Published online: 10 August 2003; | doi:10.1038/ni962
There is a Corrigendum (October 2003) associated with this Article.
Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo
Sanjay Garg1, Alp Oran1, Janine Wajchman2, Shin Sasaki3, Charles H Maris1, Judith A Kapp2
& Joshy Jacob1
1
Department of Microbiology and Immunology, Vaccine Research Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia 30322, USA.
2
Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA.
3
Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama, Tokyo 182-0002, Japan.
Dendritic cells (DCs) are key regulators of immune responses that activate naive antigen-specific T lymphocytes. In draining lymph nodes, antigen-bearing DCs are reported to be rare and short-lived. How such small numbers of short-lived DCs can activate rare antigen-specific T cells is unclear. Here we show that after immunization of mouse skins by gene gun, the number of antigen-bearing DCs that migrate to draining lymph node is 100-fold higher than previously estimated and that they persist for approximately 2 weeks. The substantial frequency and longevity of DCs in situ ensures ample antigen presentation and stimulation for the rare antigen-specific T cells in draining lymph nodes.
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