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News and Views
Nature Immunology  4, 825 - 826 (2003)
doi:10.1038/ni0903-825

Boosting p53 with interferon and viruses

Jan Vilc caronek

Jan Vilc caronek is at the New York University School of Medicine, New York, New York 10016, USA. jan.vilcek@med.nyu.edu

Interferon-alpha/beta proteins are vital for innate immune responses to viruses. The tumor suppressor p53 mediates cell cycle arrest and apoptosis. A recent study in Nature reports that interferon-alpha/beta stimulates p53 synthesis, demonstrating a hitherto unrecognized link.

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REFERENCE
Signal Transduction Pathways in Development: the JAK/STAT Pathway
Nature Encyclopaedia of Life Sciences

REVIEWS
A WEAK SIGNAL FOR STRONG RESPONSES: INTERFERON-ALPHA/BETA REVISITED
Nature Reviews Molecular Cell Biology Review Article (01 May 2001)
 See all 2 matches for Reviews

NEWS AND VIEWS
Novel interferons
Nature Immunology News and Views (01 Jan 2003)

RESEARCH
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
The EMBO Journal Article (16 Nov 1998)
Serine phosphorylation of STATs
Oncogene Original Article (22 May 2000)
 See all 13 matches for Research

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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