Mark Schlissel is in the Department of Molecular and Cell Biology, University of California, Berkeley, 439 LSA, Berkeley, California 94720-3200, USA. mss@uclink4.berkeley.edu
Early B cell development faces a critical checkpoint at the pro-B pre-B transition stage, at which proper assembly and surface expression of an immunoglobulin heavy chain is somehow signaled by the pre-B cell receptor. Triggering of this signal might not require exogenous ligands.
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pre-B transition stage, at which proper assembly and surface expression of an immunoglobulin heavy chain is somehow signaled by the pre-B cell receptor. Triggering of this signal might not require exogenous ligands.
5 mediates cell-autonomous pre-B cell receptor signaling
