Melissa Pope is at the Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA. mpope@popcbr.rockefeller.edu
Nef-expressing macrophages induce activation of resting T lymphocytes, permitting productive HIV-1 infection. A recent report in Nature defines just how Nef manipulates macrophage signaling to enhance T cell infectivity.
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