Robert T. Abraham is in the Program in Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. abraham@burnham.org
Rap1 mediates 'inside-out' signaling from the T cell receptor to LFA-1. The discovery of RAPL, a Rap1-binding molecule, helps explain how Rap1 induces T cell adhesion.
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