Nature Immunology
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July 2003 - Vol 4 No 7
Nature Immunology 4 (2003)
 
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The control of DNA accessibility is a theme throughout our Focus on Chromatin Dynamics (pages 601−639; free online until the end of September 2003). Like the intricate braids of Leda as sketched by Leonardo da Vinci, chromatin has various states. Heterochromatin is as inaccessible as tightly coiled braids (1), loose curls (2) represent more accessible DNA, and untwined strands (3) resemble the opened templates necessary for replication or transcription into RNA (4). [Original image © Alinari Archives/CORBIS]
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