T-bet: The Toll-bridge to class-switch recombination?
Ian R Rifkin
& Ann Marshak-Rothstein
Ian R. Rifkin is in the Department of Medicine and Ann Marshak-Rothstein is in the Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. irifkin@bu.edu and amrothst@bu.edu
CpG signaling through TLR9 elicits type 1 cytokine production, which can suppress IgE-associated hypersensitivity reactions. CpG also acts directly on B cells by inducing STAT1-independent T-bet expression.
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