The author is in the Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA. mdavis@pmgm2.stanford.edu
The anti-influenza CD8+ T cell response in HLA-A2 adults is dominated by a specific TCR. The crystal structure of the TCR and peptide-MHC complex show unusual interactions that help to explain the molecular basis of this dominant TCR selection.
