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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Immunology  4, 432 - 433 (2003) doi:10.1038/ni0503-432 Linking Toll-like receptors to IFN-/ expression Gregory M. Barton & Ruslan Medzhitov Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar St., CAB S660, New Haven, CT 06520. Correspondence should be addressed to Ruslan Medzhitov ruslan.medzhitov@yale.eduMany infectious agents elicit a type I interferon response, but the molecular details that lead to IFN-/ expression have remained obscure. New details are emerging about how specific TLRs signal IFN-/ expression. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS Toll-like receptors: critical proteins linking innate and acquired immunity Nature Immunology Review Article (01 Aug 2001)  See all 14 matches for Reviews NEWS AND VIEWS Toll signaling: RIPping off the TNF pathway Nature Immunology News and Views (01 May 2004) Toll signaling: the TIReless quest for specificity Nature Immunology News and Views (01 Feb 2003)  See all 15 matches for News And Views RESEARCH TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway Nature Immunology Article (01 Nov 2003) RIP1 is an essential mediator of Toll-like receptor 3–induced NF-B activation Nature Immunology Article (01 May 2004)  See all 38 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... Novel Approaches to Protecting Maize from Insect Damage Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... More Challenges Powered by: nature jobs Sr. Scientific Manager / Chief Scientific Manager- Discovery Metabolism and Pharmacokinetics (MAP) Syngene International Bangalore, Karnataka 560099 India Professor of Experimental Virology (W3) University Hospital Jena, Institute of Virology and Antivirale Therapy Jena, Germany More science jobs Post a job for free Figures & Tables See also: Article by Fitzgerald et al. Export citation Search buyers guide:   ADVERTISEMENT

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