Nature Immunology4, 380 - 386 (2003)
Published online: 24 February 2003; | doi:10.1038/ni903
Transcriptional profiling identifies Id2 function in dendritic cell development
Christine Hacker1, 5, Ralf D. Kirsch1, 5, Xin-Sheng Ju1, Thomas Hieronymus1, Tatjana C. Gust1, Christiane Kuhl1, 4, Thorsten Jorgas1, Steffen M. Kurz1, Stefan Rose-John2, Yoshifumi Yokota3
& Martin Zenke1
Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2-/- mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)- also lack LCs, and we demonstrate here that, in DCs, TGF- induces Id2 expression. We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-−Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors.
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+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-
also lack LCs, and we demonstrate here that, in DCs, TGF-
