Proteases, proteases and proteases for presentation
Carla Herberts, Eric Reits
& Jacques Neefjes
Division of Tumor Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam
Correspondence should be addressed to Jacques Neefjes j.neefjes@nki.nl
Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.
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