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Nature Immunology  4, 303 - 304 (2003)
doi:10.1038/ni0403-303

Knowing one's self: central tolerance revisited

Jonathan Sprent & Charles D. Surh

Department of Immunology, IMM4, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037

Correspondence should be addressed to Jonathan Sprent jsprent@scripps.edu
Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New data on T cell tolerance in AIRE-/- mice strongly support this hypothsis.

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REFERENCE
Thymus
Nature Encyclopaedia of Life Sciences

REVIEWS
Cell death and immunity: Negative selection — clearing out the bad apples from the T-cell repertoire
Nature Reviews Immunology Review (01 May 2003)

NEWS AND VIEWS
Immunology: Education and promiscuity
Nature News and Views (05 Dec 2002)

RESEARCH
Aire regulates negative selection of organ-specific T cells
Nature Immunology Article (01 Apr 2003)

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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