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Volume 4 Issue 3, March 2003

A mouse Paneth cell (bottom image) in the abstract style of Swiss painter Paul Klee (1879-1940). Hooper et al. (page 270) report that angiogenin 4 is microbicidal and released from distinctive granules (red) in these cells at the base of the crypts of the small intestine, in response to indigenous gut bateria. Electron micrograph by T.S. Stappenbeck, rendering by Lewis Long.

Volume 4 Issue 3

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Editorial

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Commentary

  • Due to an ever-increasing elderly population, there is a mounting drive to understand immunological defects associated with aging. However, the history of aging research and the very nature of the research itself has hampered progress.

    • Richard Aspinall
    • Sian M. Henson
    • Jeffrey Pido-Lopez
    Commentary
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News & Views

  • How autoreactive thymocytes die remains a question that has not been fully answered. New results supporting a role for the death ligand TRAIL may take us a step closer to unraveling this mystery.

    • Douglas R. Green
    News & Views

  • The idea that genes are transcriptionally activated by rapid CpG demethylation has been controversial. New data provides the most compelling evidence yet, implicating a mysterious enzyme activity that can actively demethylate DNA.

    • Adrian Bird
    News & Views

  • The lineage relationships of TEM and TCM and their ability to confer protective immunity are not well understood. New data suggest TEM are poorer mediators of protective immunity and convert to TCM over time.

    • Vladimir P. Badovinac
    • John T. Harty
    News & Views

  • Angiogenin was discovered as an inducer of blood vessel formation. However, a new study implicates it in antimicrobial host defense.

    • Tomas Ganz
    News & Views
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